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Indications about Everlong Tablets in Pakistan
Indicated for the treatment of premature ejaculation (PE) in
men 18 to 64 years of age, who have all of the following:
Persistent or recurrent ejaculation with minimal sexual
stimulation before, on or shortly after penetration and before the patient
wishes.
Marked personal distress or interpersonal difficulty as a
consequence of PE and poor control over ejaculation.
Everlong Tablets in Pakistan for Erectile Dysfunction
Pharmacology
The mechanism of action is thought to be related to
inhibition of neuronal reuptake of serotonin and subsequent potentiating of
serotonin activity. The central ejaculatory neural circuit comprises spinal and
cerebral areas that form a highly interconnected network. The sympathetic,
parasympathetic, and somatic spinal centers, under the influence of
sensorygenital and cerebral stimuli integrated and processed at the spinal cord
level, act in synergy to command physiologic events occurring during
ejaculation. Experimental evidence indicates that serotonin (5-HT), throughout
brain descending pathways, exerts an inhibitory role on ejaculation. To date,
three 5-HT receptor subtypes 5-HT (1A), 5-HT (1B), and 5-HT (2C) have been
postulated to mediate 5-HT's modulating activity on ejaculation.
Dosage & Administration of Everlong Tablets in Pakistan
Adult (18 to 64 years of age): The recommended starting dose
for all patients is 60 mg, taken as needed approximately 1 to 3 hours prior to
sexual activity. If the effect of 30 mg is insufficient and the side effects
are acceptable, the dose may be increased to the maximum recommended dose of 60
mg. The maximum recommended dosing frequency is one dose every 24 hours.
Interaction of Everlong Tablets in Pakistan
CNS active medicinal products: The use of Everlong Tabletsin Pakistan in combination with CNS active medicinal products has not been
systematically evaluated in patients with premature ejaculation. Consequently,
caution is advised if the concomitant administration of Everlong Tablets in
Pakistan and such medicinal products is required.
PDE5 inhibitors: Tadalafil did not affect the
pharmacokinetics of Everlong Tablets in Pakistan. Sildenafil caused slight changes
in Everlong Tablets in Pakistanpharmacokinetics, which are not expected to be
clinically significant. However, Everlong Tablets in Pakistan should be
prescribed with caution in patients who use PDE5 inhibitors due to possible
reduced orthostatic tolerance.
Tamsulosin: Concomitant administration of single or multiple
doses of 30 mg or 60 mg Everlong Tablets in Pakistan to patients receiving
daily doses of Tamsulosin did not result in changes in the pharmacokinetics of
Tamsulosin. However, Everlong Tablets in Pakistan should be prescribed with
caution in patients who use alpha adrenergic receptor antagonists due to
possible reduced orthostatic tolerance.
Warfarin: There are no data evaluating the effect of chronic
use of Warfarin with Everlong Tablets in Pakistan; therefore, caution is
advised when Everlong Tablets in Pakistan is used in patients taking Warfarin
chronically.
Ethanol: Concomitant use of alcohol and Everlong Tablets inPakistan could increase the chance or severity of adverse reactions such as
dizziness, drowsiness, slow reflexes, or altered judgment. Combining alcohol
with Everlong Tablets in Pakistan may increase these alcohol-related effects
and may also enhance neurocardiogenic adverse events such as syncope, thereby
increasing the risk of accidental injury; therefore, patients should be advised
to avoid alcohol while taking Everlong Tablets in Pakistan.
Contraindications with Everlong Tablets in Pakistan
Patients with known hypersensitivity to Everlong Tablets in Pakistan Hydrochloride.
Patients with significant pathological cardiac conditions
such as heart failure (NYHA class II-IV), conduction abnormalities (second or
third degree AV block or sick sinus syndrome) not treated with a permanent
pacemaker, significant ischemic heart disease of significant alular disease.
Concomitant treatment with monoamine oxidize inhibitors
(MAOIs), thioridazine. Similarly, MAOIs or thioridazine should not be
administered within 7 days after Everlong Tablets in Pakistan has been
discontinued.
Concomitant treatment with serotonin reuptake inhibitors
(SSRIs), serotonin-nor epinephrine reuptake inhibitors (SNRIs), tricycle
antidepressants (TCAs) or other medicinal/herbal products with serotonergic
effects or within 14 days of discontinuing treatment with these medicinal/herbal
products.
Side Effects of Everlong Tablets in Pakistan
Dizziness, Headache, Somnolence, Tremor, Blurred vision,
Tinnitus, Sinus congestion, Nausea, Diarrhea, Abdominal pain, Dry mouth,
Fatigue, Insomnia, Hypertension.
Pregnancy & Lactation using Everlong Tablets in Pakistan
Everlong Tablets in Pakistan is not indicated for use by
women. It is not known either Everlong Tablets in Pakistan or its metabolites
are excreted through human breast milk.
Precautions about Everlong Tablets in Pakistan
Patient with bleeding disorders, epilepsy, susceptibility to
angle-closure glaucoma or raised intraocular pressure. Not intended for use in
women. Known CYP2D6 poor metabolize.
Overdose Effects of Everlong Tablets in Pakistan
There were no unexpected adverse events in a clinical
pharmacology study of Everlong Tablets in Pakistan with daily doses up to 240
mg. In general, symptoms of overdose with SSRIs include serotonin-mediated
adverse reactions such as somnolence, gastrointestinal disturbances such as
nausea and vomiting, tachycardia, tremor, agitation and dizziness. In cases of
overdose, standard supportive measures should be adopted as required.
Storage Conditions of Everlong Tablets in Pakistan
Store below 30°C. Protect from light and moisture. Keep
outof reach of children
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